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This abstract is assigned to session OB Free papers: Oncologie

Title	S100 in screening for uveal melanoma metastases
Abstract Nr.	333

Purpose	To investigate the role of the S100 serum test in the follow-up of uveal melanoma patients for metastases. In skin melanoma S100 serum test is successfully used for screening for metastases and monitoring of systemic therapy.
Methods	30 patients (< 70 years) with a uveal melanoma with a diameter > 10 or a height > 5 mm were included in the study. The patients were followed up with liver function tests, S100 serum test and liver ultrasound, every 6 months during 5 years.
Results	During follow-up 6 patients developed metastases from their uveal melanoma. In 5 patients, metastases were first detected by liver ultrasound, in 1 patient with a S100 serum test.
Conclusion	S100 serum test is a useful test for the identification of uveal melanoma metastases and could identify metastases better than liver function tests. Nevertheless, liver ultrasound could detect uveal melanoma metastases earlier than any of the serum tests. S100 serum test may be useful in the monitoring of systemic therapy.

Author 1

Last name	MISSOTTEN
Initials	GS
Department	Leiden University Medical Center, Nederland & Catholic University Leuven, Belgium
City	Leiden - Leuven

Author 2

Last name	Bonfrer
Initials	JG
Department	The Netherlands Cancer Institute, Nederland
City	Amsterdam

Author 3

Last name	Van der Velden
Initials	P
Department	Leiden University Medical Center, Nederland
City	Leiden

Author 4

Last name	Jager
Initials	MJ
Department	Leiden University Medical Center, Nederland
City	Leiden

Author 5

Last name	Luyten
Initials	GP
Department	Leiden University Medical Center, Nederland
City	Leiden