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This abstract is assigned to session OB Free papers: Oncologie

Title	Epistaxis or Epiphora as sign for extension of a conjunctival melanoma. A series of six patients with nasolacrimal recurrence
Abstract Nr.	332

Purpose	To characterize malignant conjunctival melanomas with extension and recurrence in the lacrimal duct and nose.
Methods	Localization of the primary tumor and recurrences of 210 conjunctival melanomas treated in the Netherlands were reviewed for orbital and nasal tumors (1978-2008). On the basis of these cases and literature data, characteristics for lacrimal duct and nose extension and metastasis were reviewed.
Results	Six patients (3%) showed a secondary conjunctival melanoma in the nose. Two of the six primary tumors were epibulbar, the other 4 were multifocal tumors involving the fornix. All primary conjunctival melanomas were associated with primary acquired melanosis (PAM). During follow-up period (mean 139 ± 37 months; median 105 months) two patients developed metastases, and died during follow-up.
Conclusion	Ophthalmologists treating conjunctival melanoma should be aware of the possible extension of conjunctival melanomas in the lacrimal duct and nose, especially in non-epibulbar cases associated with PAM. Screening for conjunctival melanoma recurrences should include the active questioning of epiphora, nose obstructions and epistaxis.

Author 1

Last name	MISSOTTEN
Initials	GS
Department	Leiden University Medical Center, Nederland & Catholic University Leuven, België
City	Leuven - Leiden

Author 2

Last name	Gambrelle
Initials	J
Department	Lyon University Hospital, France
City	Lyon

Author 3

Last name	De Wolff-Rouendaal
Initials	D
Department	Leiden University Medical Center, Nederland
City	Leiden

Author 4

Last name	De Keizer
Initials	RJ
Department	Leiden University Medical Center, Nederland & Antwerp University, België
City	Leiden - Antwerpen