View abstract

This abstract is assigned to session OB Poster session > in poster area

Title	Birdshot-like chorioretinopathy in lymphoid interstitial pneumonia due to hypogammaglobulinopathy
Abstract Nr.	134

Purpose	To describe a patient with a birdshot-like choroidoretinopathy secondary to a hypogammaglobulinopathy, complicated with lymphoid interstitial pneumonia and persistent lymphadenopathy.
Methods	An 18 - year old girl presented with an asymptomatic bilateral papillary oedema and chorioretinal infiltrates. These findings were noted during routine follow-up for hydroxychloroquin (HCQ) use. She underwent a full ophthalmological and systemic work-up, including electroretinography and fluorescein and ICG angiographies.
Results	This patient was diagnosed with a lymphoid interstitial pneumonia due to a hypogammaglobulinopathy at the age of 13. Since then she’s treated with monthly intravenous immunoglobulines and oral HCQ. Annual visits to exclude hydroxychloroquine toxicity revealed no abnormalities until 2 years ago. One year ago visual acuity was 12/10 without correction in both eyes. Slit-lamp examination was unremarkable. However, fundoscopy revealed bilateral papilloedema and chorioretinal infiltrates with a birdshot-like appearance. On fluo-angiography a bilateral hot disc was present, whilst the chorioretinal infiltrates were hypofluorescent on ICG. ERG and colour vision were normal. MRI brain revealed no signs of raised intracranial pressure. HLA- A29 analysis was negative, as were the blood levels of ACE.
Conclusion	Hypogammaglobulinopathy complicated with lymphoid interstitial pneumonia may present with an HLA-A29 negative phenocopy of Birdshot choroidoretinopathy.

Author 1

Last name	DE MAEYER
Initials	V
Department	Dept of Ophthalmology, Ghent University Hospital
City	Ghent

Author 2

Last name	KESTELYN
Initials	P
Department	Dept of Ophthalmology, Ghent University Hospital
City	Ghent

Author 3

Last name	HAERYNCK
Initials	F
Department	Dept of Paediatrics, Ghent University Hospital
City	Ghent

Author 4

Last name	DE BAETS
Initials	F
Department	Dept of Paediatrics, Ghent University Hospital
City	Ghent

Author 5

Last name	LEROY
Initials	BP
Department	Dept of Ophthalmology, Ghent University Hospital
City	Ghent