View abstract

This abstract is assigned to sessions

Title

Exploration of Structural and Functional Parameters in Bilateral Temporal Optic Neuropathy

Purpose	To evaluate the correlation between structural and functional parameters and the diagnostic value of OCT in a group of patients with OCT documented bilateral optic neuropathy limited to the papillomacular bundle.
Methods	Retrospective study.
Results	We included 61 patients. The strongest positive relationship between best-corrected visual acuity (BCVA) and tested OCT parameters was with macular GCL (ganglion cell layer) and GCIPL (combined ganglion cell & inner plexiform layer) volumes rather than global or temporal peripapillary retinal nerve fiber layer (RNFL) measurements (all statistically significant). There was an inverse relationship between BCVA and inner nuclear layer (INL) volumes, with significant differences for BCVA and all tested OCT parameters between eyes with and without INL microcystoid lesions. However, while thicker INL was correlated with more severe disease, it was not helpful in the differential diagnosis. OCT (both absolute values and intereye differences) was not helpful in distinguishing between presumed acquired mitochondrial disease and eyes with multiple sclerosis without optic neuritis. When compared to patients with a previous history of unilateral optic neuritis, significantly greater intereye differences in global RNFL (but not temporal RNFL) and IPL and GCIPL volumes were found in the latter.
Conclusion	The strongest positive relationship with BCVA was found for macular GCL and GCIPL volumes. OCT (absolute values and/or intereye differences) was not helpful in the differential diagnosis between presumed acquired mitochondrial disease and patients with multiple sclerosis without optic neuritis.
Conflict of interest	No

Authors 1

Last name	BUELENS
Initials	T
Department	CHU St Pierre & Brugmann, Ophthalmology
City	Brussels

Authors 2

Last name	Fils
Initials	JF
Department	Ars Statistica SPRL
City	Nivelles

Authors 3

Last name	Willermain
Initials	F
Department	CHU St Pierre & Brugmann, Ophthalmology
City	Brussels