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Title

Outcome after Intracameral Dexamethasone Injection Due to Endothelial Immune Reaction after Keratoplasty

Purpose	To evaluate the effectiveness of intracameral dexamethasone injection (IDI) after endothelial immune reaction (EIR) and the role of the laser flare meter (LFM) for diagnostic and follow-up.
Methods	This study included 50 eyes presenting with an EIR after penetrating keratoplasty (PKP) (n = 46) or DMEK (n = 4). All patients received an IDI (400µg dexamethasone). We analyses the best corrected visual acuity (BCVA), the central corneal thickness (CCT) and corneal volume (CV) and the anterior chamber flare (ACF) preoperatively, 6 weeks and 6 months following the IDI.
Results	The BCVA increased from LogMar 1.03 +/- 0.62 to 0.7 +/- 0.56 (p < 0.001) and 0.84 +/- 0.65 (p = 0.03) at 6 weeks and 6 months after IDI. For the same periods of measures, the CCT decreased from 833 +/- 384 µm to 661 +/- 169 (p < 0.001) and 601 +/- 89 µm (p < 0.001). The CV decreased from 79 +/- 12 mm^3 to 71 +/- 12 (p < 0.001) and 70 +/- 12 mm^3 (p = 0.01). The ACF varied from 23 +/- 22 phot/ms to 25 +/- 24 (p = 0.96) at 6 weeks after IDI.
Conclusion	The ICI seems to be an effective and secure adjuvant approach for treatment of EIR after PKP or DMEK. ACF is probably not an accurate method to evaluate the EIR, presumably due to the poor quality of the measurements through the decompensated cornea and corneal opacities.
Conflict of interest	No

Authors 1

Last name	HAMON
Initials	L
Department	Saarland University Medical Center (UKS)
City	Homburg/Saar, Germany

Authors 2

Last name	DAAS
Initials	L
Department	Saarland University Medical Center (UKS)
City	Homburg/Saar, Germany

Authors 3

Last name	MILIOTI
Initials	G
Department	Saarland University Medical Center (UKS)
City	Homburg/Saar, Germany

Authors 4

Last name	LAURIK
Initials	KL
Department	Saarland University Medical Center (UKS)
City	Homburg/Saar, Germany

Authors 5

Last name	HARTMANN
Initials	M
Department	Saarland University Medical Center (UKS)
City	Homburg/Saar, Germany

Authors 6

Last name	XANTHOPOULOU
Initials	K
Department	Saarland University Medical Center (UKS)
City	Homburg/Saar, Germany

Authors 7

Last name	SEITZ
Initials	B
Department	Saarland University Medical Center (UKS)
City	Homburg/Saar, Germany