THE BELGIAN OPHTHALMIC ASSOCIATIONS
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This abstract is assigned to session BOG-SBO: Glaucoma / Glaucome
| Title | Optic disc hemorrhages and progression to glaucoma in the European Glaucoma Prevention Study (EGPS) |
| Abstract Nr. | 171 |
| Purpose | To determine the predictive value of optic disc hemorrhages (ODHs) for the development of glaucoma. |
| Methods | The European Glaucoma Prevention Study was designed to evaluate whether reducing the intra-ocular pressure in patients with ocular hypertension might reduce the risk of progression to glaucoma. All eyes included in the EGPS study were monitored for optic disc hemorrhages (ODHs) every 6 months for 5 years both by fundoscopy and evaluation of optic disc stereo-photographs. Chi-square test was used to compare the rates of progression |
| Results | 1923 eyes of 1081 participants were analyzed. Thirty-three eyes (1.7%) developed ODHs on at least one occasion. The total percentage of eyes that developed glaucoma was 6,1% (117 out of 1923 eyes). Of patients that developed glaucoma, 18.2% (6 out of 33) had a previous ODH, whereas 5.9% (111 out of 1890) did not have a history of ODH (p=0.0127 by Fisher Exact test). Using a Cox Regression test with time-varying covariate, taking into account both the differences in follow-up and the moment of occurrence of the ODH between the patients, the hazard ratio for the first occurrence of ODH was 4.55 (p=0.001). Finally, to overcome the problem of clustering of the eyes within a patient, and the presence of interval-censoring, a hazard ratio was calculated for each of the 10.000 non-parametric bootstrap samples. The mean hazard ratio was still 3.97, although this relation was only borderline significant (p=0.06). |
| Conclusion | These results indicate that optic disc hemorrhages are associated with an increased risk of conversion to glaucoma. |
Author 1
| Last name | STALMANS |
| Initials | I |
| Department | UZ Leuven |
| City | Leuven |
Author 2
| Last name | ZEYEN |
| Initials | T |
| Department | UZ Leuven |
| City | Leuven |
Author 3
| Last name | MIGLIOR |
| Initials | S |
| Department | Universita Milano Biccocca |
| City | Monza |
Author 4
| Last name | PFEIFFER |
| Initials | N |
| Department | Meinz University |
| City | Meinz |
Author 5
| Last name | CUNHA-VAZ |
| Initials | J |
| Department | Azinhaga Santa Combra |
| City | Coimbra |
Author 6
| Last name | ADAMSONS |
| Initials | I |
| Department | Lafayette Hill |
| City | Lafayette Hill, PA |
Author 7
| Last name | EGPS study group |