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This abstract is assigned to session AOB FP
TitlePeripapillary and Macular Neurovascular Coupling in Dominant Optic Atrophy
PurposeNeurodegeneration is part of Dominant Optic Atrophy (DOA).We aim to evaluate the macular and peripapillary neurovascular coupling in DOA, using coherence tomography (OCT) and OCT angiography (OCTA).
MethodsProspectively-defined, cross-sectional case-control study. Consecutive patients with a clinical and/or genetic diagnosis of DOA along with age and sex-matched controls were included. The radial peripapillary capillary (RPC) density and vessel density (VD) in the parafoveal superficial and deep capillary plexuses (SCP and DCP, respectively) were evaluated with OCTA. The ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) thickness were determined using structural OCT. We applied a previously validated customized macro (Fiji, SciJava Consortium) to compute RPC density. The remaining parameters were calculated by the built-in software. Non-parametric methods were used for data analysis. The target alpha level was 0.05, which was adjusted through Bonferroni’s correction when multiple outcomes were tested.
ResultsFifty-eight eyes (n=29 control; n=29 DOA) from 30 subjects (mean age 42.43±15.30 years; 37.93% male) were included. Parafoveal SCP VD, GCC thickness, temporal quadrant of RPC and nasal and temporal quadrants of RNFL were decreased in DOA eyes (all p<0.001). In the DOA group, RPC (annular and temporal quadrant) negatively correlated with RNFL thickness (temporal and nasal quadrants), respectively. The GCC:Parafoveal SCP ratio was increased in DOA, relatively to matched controls. In contrast, the temporal RNFL:RPC ratio was decreased in DOA eyes.
ConclusionBoth microvascular and structural peripapillary damage were found in DOA but measures of neurovascular coupling suggest that such changes may occur differently for the macula and peripapillary regions.
Conflict of interestNo
Authors 1
Last nameMARQUES
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